CD274 and cancer: This observation is in line with the data reported by Van Schaeybroeck et al. concerning MET influence on the JAK–STAT-3 pathway.58 Beside the implications on PD-L1/L2 transcription, our data add a new and potentially relevant piece of information on the complex molecular network of MET, considering the multiple biologic functions mediated by JAK kinases in normal and cancer cells.