However, in controls, percentage promoter DNA methylation of PBMCs exhibit strong negative associations with serum total cholesterol levels, showing Pearson correlation coefficients (r) of −0.6161 (p = 0.0029), −0.4694 (p = 0.0207) and −0.5512 (p = 0.0052), respectively, for IL12b, STAT1 and JAK2. The percentage DNA methylation of IL12b, iNOS, MHC2 and SOCS5 showed negative correlation with hypertension, whereas the percentage DNA methylation of STAT1, STAT6, JAK1 and JAK2 showed positive correlation with hypertension in CAD patients, although non-significant. The gene discussed is SOCS5; the disease is Hypertension.