CA has been reported to display antiproliferative properties in human umbilical vein endothelial cells (HUVECs) (50% effective concentration [EC50], 0.35 μM) and antileukemic activity in CA-sensitive AML cell lines (50% inhibitory concentration [IC50] ∼10 nM) by selectively inhibiting CDK8 activity (7, –, 9). This evidence concerns the gene CDK8 and acute myeloid leukemia.