MDM2 and cancer: MDM2 levels are elevated in a variety of cancers (reviewed in (Rayburn et al. 2005)) and this elevation has been attributed in some cases to an increase in translation of the pool of MDM2 transcripts, based on increased transcription from the P2 (Landers et al. 1997; Capoulade et al. 1998; Brown et al. 1999).