Higher copy-number ratios were significantly enriched for genes commonly amplified in tumors such as oncogenes, e.g., CCND1 and EGFR, conversely copy-number ratios smaller than one were enriched, but not significantly, for known tumor suppressors, e.g., CDKN2A and TP53 (Additional file 1: Figure S3a, Additional file 3: Table S2). The gene discussed is EGFR; the disease is neoplasm.