Global analysis of receptor tyrosine kinase (RTK) phosphorylation using an antibody array in mice subjected to 60 min of MCAO followed by 6 h reperfusion revealed significantly increased phosphorylation of certain EphB receptor family members including EphB2 within the left ipsilesional cerebral hemisphere (Fig. 1b; phosphorylation status of 39 different murine RTK analyzed post stroke is shown in Additional file 1: Figure S2a) while total EphB2 protein amount did not differ between contra- and ipsilateral brain tissue (Additional file 1: Figure S1a). This evidence concerns the gene EPHB2 and stroke disorder.