However, our study revealed that neither cerebrovascular anatomy, capillary density, and pericyte coverage, nor the reduction in rCBF upon MCAO was altered in Ephb2-deficient as compared to WT mice suggesting that loss of EphB2 does not directly affect the phenotype of vascular cells in response to cerebral ischemia. The gene discussed is EPHB2; the disease is Cerebral ischemia.