FSTL1 and Kyphoscoliosis: The finding that Fstl1 KO mice display both abnormal spine curvature and respiratory distress at birth can also point toward kyphoscoliosis, a musculoskeletal disorder characterized by an abnormal curve of the spine that causes extrapulmonary restriction of the lungs that further results in impairment of pulmonary functions (Pajdzinski et al., 2017).