MAPT and tauopathy: In vivo animal models have furthermore demonstrated an active role of microglial activation and IL-1β in the pathogenetic process of Tauopathies [6, 101], and indicated microgliosis associated with early or soluble Tau aggregates and preceding the development of full-blown mature neurofibrillary tangles (NFTs) [26, 45, 53, 78, 101].