Directheparitinase digestion through heparitinase existing inglomerular basement membranes results in a loss of membrane function.10 In patients with DN, loss of HSPG inglomerular extracellular matrices has been reported.11 Both the urinary and plasma levels of heparanase have been reportedto be elevated in type 2 diabetes. Here, HPSE is linked to liver dysplastic nodule.