HPSE and liver dysplastic nodule: Heparanase activity, anendoglycosidase that specifically cleaves HS side chains of HSPG, has been observedin both type 1 and type 2 diabetic patients with proteinuria.12,13Therefore, loss of HS in the glomerular basement membrane resultsin a decrease of the anionic charge barrier and may possibly be one of the majorcauses of proteinuria in DN.