For penicillin, these are the efficiencies registered: anaphylactic allergic reaction, immunoglobulin E (IgE) 10%, urticaria rash; nontoxic antibiotic; eosinophilia 1–2%, 6–9%, late reaction of IgG/IgM: 1–5%; nephritis, fever, eosinophilia, hematuria: 1–2%; hematological reactions, hemolytic anemia, immune thrombocytopenia, leukopenia 1–5%; nervous system: epileptogenic action, encephalopathy; gastrointestinal system: diarrhea, pseudomembranous colitis, dysbacteriosis; cross allergy 10%; problems in the balance of electrolytes (Na, K). This evidence concerns the gene IGHE and allergic disease.