The GK rats showed moderate elevation in plasma glucose level (control, 4.92 ± 0.51 mM vs. diabetic 7.87 ± 0.85 mM), impaired glucose tolerance (Figure 1A,B) and decreased insulin sensitivity (Figure 1C); determined by the so called homeostasis model assessment of insulin resistance (HOMA-IR). The gene discussed is INS; the disease is Insulin resistance.