PTEN and urogenital neoplasm: Shao et al. reported that FGF-FGFR signaling plays an important role in transformation induced by the loss of a PTEN tumor suppressor when combined with the expression of the TMPRSS2/ERG fusion gene [26], and activation of FGF-FGFR signaling by FGF8b overexpression in PTEN deficiency is reported to be associated with prostate tumorigenesis [27].