MAPT and Alzheimer disease: The 290KCGSKD295 motif, which adopts a very similar conformation to the homologous 353KIGSLD358 and 259KIGSTE263 motifs in the tau filament structures from AD and PiD, respectively (Falcon et al., 2018b; Fitzpatrick et al., 2017), connects β2 and β3.