EIF2AK3 and metabolic dysfunction-associated steatotic liver disease: In 2015, a study reported that Berberine (BBR) can upregulate the expression of lncRNA MRAK052686 and its target genes Nrf2 and Eif2ak2 in a high-fat diet- (HFD-) induced steatotic animal model, thereby inhibiting the PERK (PKR-like ER-kinase) pathway in ER stress, indicating that lncRNA MRAK052686 plays a role in NAFLD by affecting ER stress.