Obesity and type 2 diabetes promote liver overload of glucose and insulin, which can activate carbohydrate response element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c), respectively, thereby upregulating glycolytic enzymes and fatty acid synthase to promote hepatic lipogenesis [25]. This evidence concerns the gene MLXIPL and obesity due to melanocortin 4 receptor deficiency.