Furthermore, within the population of macrophages with high CD206 expression, there was higher expression of CD11b, CD11c, CD32, CD80, CD86, CD163, CD192, and HLA-DR in obesity, suggesting that these macrophages were activated and shared components of both classical M1 and M2 expression patterns (Figure 2). The gene discussed is ITGAM; the disease is obesity due to melanocortin 4 receptor deficiency.