Therefore, it is of interest to investigate how proinflammatory cytokines, particularly IL-6 which is elevated in T2DM, contribute to vascular damage resulting in SVGF and how suppression of proinflammatory cytokine responses via targeting the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway could be exploited as a potential therapeutic strategy. Here, IL6 is linked to type 2 diabetes mellitus.