TIMP2 and pachyonychia congenita: The AUC for TIMP-2 (0.6037, p = 0.013) was higher than for MMP-2 (0.5624, p = 0.146), but lower than AUC for classical tumor marker (CA 19-9 – 0.8583, p < 0.001; CEA – 0.8790, p < 0.001) in the differentiation between PC patients versus healthy subjects (Figure 2).