TIMP2 and pachyonychia congenita: Moreover, in the differentiation between PC and CP patients, the AUC for TIMP-2 (0.6532, p = 0.004) was higher than for MMP-2 (0.5378, p = 0.47), but lower than AUC for classical tumor marker (CA 19-9 – 0.7765, p < 0.001; CEA – 0.7193, p < 0.001) (Figure 3).