They found that, 10 min of limb reperfusion after 10 min of limb ischemia increased plasma ApoA-I by 30% compared to untreated control group, whilst 5 min of limb reperfusion after 10 min of limb ischemia did not change the plasma ApoA-I level compared to the untreated rats. This evidence concerns the gene APOA1 and limb ischemia.