It must be emphasized that mutation burden is considered predictive of a benefit for checkpoint inhibition and EGFR-mutated lung cancer was shown to have low mutation burden [9]; on the other hand, in the Italian cohort of the Nivolumab Expanded Access Program, the presence of EGFR mutations seems to affect short-term (Overall Response Rate (ORR) and Dynamic Condition Response (DCR)) but not medium- (Progression Free Survival (PFS)) or long-term (Overall Survival (OS)) outcomes [10]. The gene discussed is EGFR; the disease is lung carcinoma.