Currently, there are multiple NIR dye conjugates targeted to various receptors such as the folate receptor, [33, 34] PSMA, [35] CAIX, [36–38] CCK2R, [39–41] and NK1R [42] etc. Despite the availability of these targeted NIR dye conjugates, many cancers cannot be imaged either due to the complete absence of or presence of only very low number of these receptors. The gene discussed is CA9; the disease is cancer.