RASGRF2 and neoplasm: To ascertain that the increase in AnxA6 levels which is accompanied by relatively lower RasGRF2 levels as demonstrated in Figure 2, was associated with decreased tumor growth, we implanted empty vector transfected HCC1806 cells (1806-EV) and flag-tagged AnxA6-transfected HCC1806 (1806-Anx6) cells (2 × 106 cells/mouse) into mammary fat pads of Nu/J mice.