Since Ca2+ influx is modulated by AnxA6 and RasGRF2 promotes cell growth and inhibits cell motility, our data suggest that high RasGRF2/low AnxA6 may define rapid tumor growth and poor invasiveness while low RasGRF2/high AnxA6 may be associated with invasive but slow growing tumors. Here, RASGRF2 is linked to neoplasm.