RASGRF2 and breast carcinoma: On the contrary, up-regulation of AnxA6 in the basal-like HCC1806 cells (Figure 2G and 2H) and MDA-MB-468 cells (Supplementary Figure 5) resulted in a decrease in RasGRF2 expression and this was also confirmed in 11 basal-like breast cancer cell lines at the mRNA level (Figure 2I).