However, significant down-regulation (>70 %) of AnxA6 in the BT-A6sh5 cells led to latent (~50 days) xenograft tumor formation (Figure 3A) while implantation of the same number of AnxA6 deficient BT-A6A cells led to both early tumor onset (within 7 days) and rapid tumor growth that necessitated humane euthanasia of the mice within 18 days (Figure 3A–3C). The gene discussed is ANXA6; the disease is neoplasm.