EGFR and neoplasm: This model is supported by the reduced EGFR staining in AnxA6 deficient xenograft tumors, deregulated Ca2+ influx and aggressive tumor growth following significant down-regulation or loss of AnxA6, reduced RasGRF2 levels following stimulated Ca2+ influx and the stabilization of GRF2 levels following inhibition of Ca2+ entry or up-regulation of AnxA6.