On day 28, the levels of protein concentration of TGF-β1, CTGF, and hydroxyproline in the sera samples of BLM+ Pred and BLM+YYYQ groups were significantly decreased compared to that of BLM group, especially in YYYQ-M and YYYQ-H groups (p < 0.01 or p < 0.05). The gene discussed is CCN2; the disease is Bloom syndrome.