The gene expression analysis of markers and regulators of myogenic differentiation of SM-MPC derived from HD and HF patients confirmed the results of immunohistochemistry: the expression of slow skeletal muscle fiber MHC isoform MYH7 and fast isoform MYH1 did not differ significantly between HD- and HF-derived differentiated myotubes, and the expression of embryonic (MYH3) and neonatal (MYH8) myosins did not differ significantly as well. The gene discussed is MYH8; the disease is Huntington disease.