We have also detected in HF skeletal muscle the alterations in the expression of the NPRA/B-to-NPRC ratio (Figures 1(g)–1(i)) that controls the biological activity of the natriuretic peptide system (NP) at the target tissue level [26], including control of sensitivity to insulin and lipid oxidative capacity through a Pgc1a-dependent pathway [27] and cardiac progenitor cell proliferation and differentiation into cardiomyocytes [28]. The gene discussed is INS; the disease is hydrops fetalis.