We have also detected the shift in the expression ratio between fiber type I and fiber type II in skeletal muscle from HF patients, as well as the downregulation of expression of Pgc1a (Figure 1), which is an important mediator of mitochondrial metabolic properties in skeletal muscle and is downregulated in various types of atrophying muscle [37] including skeletal muscle of rats with HF [38–41]. The gene discussed is PPARGC1A; the disease is hydrops fetalis.