Furthermore, HF is a state of chronic activation of adrenergic and NP systems, which besides their well-documented role in the cardiovascular system also plays a role in favoring fat oxidative capacity in human skeletal muscle cells [42] via the activation of cGMP signaling, induction of PGC1a, and enhancement of mitochondrial respiration [27]. The gene discussed is PPARGC1A; the disease is hydrops fetalis.