In order to detect markers of HF-induced functional and metabolic alterations in skeletal muscles, the expression analysis was performed in HD- and HF-derived biopsy samples for markers and regulators of skeletal muscle development, maturation and function (Myf6, Myh3,Myh8, Myh1, Myh4, Myh9, Myh10, Myh7, TNNI2, and TTNC1), and energy metabolism, including the expression of genes that regulate lipids and glucose handling (Pgc1a, HIF1a, GLUT1, GLUT4, aP2, PLIN2, PLIN3, PPARg, ATGL, SCD1, GOS, CGI58, CD36, NPRA, NPRB, and NPRC). This evidence concerns the gene PNPLA2 and hydrops fetalis.