Additionally MAF has been shown to regulate antioxidant (Dhakshinamoorthy and Jaiswal, 2002; Kikuchi et al., 2018) and apoptotic pathways (Peng et al., 2007) that are required for NLRP3 inflammasome activation implicated in chronic kidney disease and gout (Jhang and Yen, 2017; So and Martinon, 2017). The gene discussed is MAF; the disease is gout.