Other parameters, such as vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1-alpha (Hif1-alpha), epidermal growth factor receptor (EGFR), and tumor suppressor protein p53 expression, are also of prognostic relevance and might aid in treatment response prediction in HNSCC [17, 18]. Here, EGFR is linked to head and neck squamous cell carcinoma.