To identify novel TMPRSS2-ERG regulated genes in PCa, we performed gene profiling analyzes on RNA extracted from VCaP cells (a TMPRSS2-ERG-positive, androgen-responsive PCa cell line) stably expressing shRNAs against ERG vs. non-target control (NTC) in the presence of androgens (to mimic the high androgen condition of primary PCa) or absence of androgens (to mimic the castrate condition during CRPC progression). The gene discussed is TMPRSS2; the disease is posterior cortical atrophy.