Through a comprehensive bioinformatic study to examine ERG-regulated genes, we have identified the α1 and β1 subunits (GUCY1A1, GUCY1B1) of soluble guanylyl cyclase (sGC) as major ERG-regulated endothelial genes that are also tightly associated with ERG expression in PCa patient samples. Here, ERG is linked to posterior cortical atrophy.