ERG and posterior cortical atrophy: To identify novel TMPRSS2-ERG regulated genes in PCa, we performed gene profiling analyzes on RNA extracted from VCaP cells (a TMPRSS2-ERG-positive, androgen-responsive PCa cell line) stably expressing shRNAs against ERG vs. non-target control (NTC) in the presence of androgens (to mimic the high androgen condition of primary PCa) or absence of androgens (to mimic the castrate condition during CRPC progression).