SNAP29 and Palmoplantar keratoderma: Indeed, homozygous inactivating mutations in the human SNAP29 gene are responsible for Cerebral Dysgenesis, Neuropathy, Ichthyosis, palmoplantar Keratoderma (CEDNIK; OMIM # 609528), a rare autosomal recessive syndrome characterized by congenital neurological and dermatological alterations.