In further analyses, we observed that wild type genotypes (DHFR, DHPS) were associated with HIV-seropositive patients (P-value < 0.05), indicating concomitant severity of underlying conditions and coinfections in these patients (4 out of 5 PCP patients with HIV-seropositivity had coinfections with M. tuberculosis and 2 of them died). The gene discussed is DHPS; the disease is pneumocystosis.