Recently, Newman and colleagues reported that IL13Rα2 cooperated with epidermal growth factor receptor mutant (EGFRvIII) to activate the ERK and STAT3 pathways to promote the progression of glioblastoma multiforme (GBM)17, suggesting that IL13Rα2 actively participates in multiple signal transduction pathways. The gene discussed is EGFR; the disease is glioblastoma.