As shown in Figs 4 and S4, the PECAM-1-positive vascular area in the tumour tissue derived from the SK-IL13Rα2 cells was significantly larger when compared with the tumour derived from the SK-MEL-28 cells, implying that the expression of IL13Rα2 in malignant melanoma enhanced angiogenesis. This evidence concerns the gene PECAM1 and neoplasm.