DGAT2 and Hepatic steatosis: While DGAT2 constitutes the most probable link between niacin and hepatic steatosis via regulation of hepatic triglyceride synthesis, other potential mechanisms include the expression of ATP synthase beta chain in the cell surface of hepatocytes and the transcription of ATP-binding cassette transporter A1 (ABCA1) which promotes apoAI lipidation31,32.