Moreover, this study implies that ghrelin alleviates OXA-induced contact dermatitis, IMQ-induced psoriasiform dermatitis, and TNF-α-induced inflammation in RAW264.7 cells by antagonizing TNF-α signaling, indicating that ghrelin may facilitates treatments for contact dermatitis and psoriasis through TNF-α. The gene discussed is GHRL; the disease is contact dermatitis.