Given the critical role of TNF-α in the initiation and progression of inflammation and the positive role reported for ghrelin in some inflammatory diseases, in this study, we aimed to examine whether ghrelin affects contact dermatitis and psoriasis by limiting TNF-α and to explore its molecular mechanisms, which may highlight a new direction of study for the treatment of both contact dermatitis and psoriasis. Here, TNF is linked to contact dermatitis.