CMLD011580 induced cell death in a number of cell lines of different hematological origins (Fig. 4), ex vivo showed synergy with the glucocorticoid dexamethasone against multiple myeloma (JJN3) cells and with ABT-199 towards the THL SC-1 cell line, and in vivo synergized with doxorubicin against Myr-Akt/Eμ-Myc lymphomas (Figs 3, 5 and 7). This evidence concerns the gene AKT1 and AL amyloidosis.