In contrast to YUMM1.1 tumors, there was a significant extension of survival of YOVAL1.1-bearing C57BL/6 mice co-treated with anti-PD-1 and anti-CTLA-4 therapy compared to isotype controls, with median survival of 57 days versus 40 days post tumor inoculation, respectively (Fig. 3b). The gene discussed is CTLA4; the disease is neoplasm.