These observations demonstrated that Riluzole (1 μM) improved all of the tested SCA phenotypes in both SCA2- and SCA3-iPSC-derived neurons, while Dantrolene (50 μM) exhibited more positive effects on SCA3-iPSC-derived neurons compared to those derived from SCA2 iPSCs. The gene discussed is ATXN3; the disease is autosomal dominant cerebellar ataxia.