Furthermore, MK801 (0.5 μM) improved mitochondrial function in neurons derived from both SCA-2 and SCA3-iPSCs, while NBQX (10 and 30 μM) did not significantly affect either cell death or mitochondrial function in neurons derived from both SCA-2 and SCA3-iPSCs (Fig. 5A,B). This evidence concerns the gene ATXN3 and spinocerebellar ataxia type 2.