Since 2001, when the full-length cDNA of PKD2 was isolated18, studies have been conducted and revealed PKD2 to be high expressed in multiple tumors, including prostate, pancreatic, colorectal, gastric, hepatocellular carcinoma, malignant human lymphomas, and Glioblastoma multiforme21–24. The gene discussed is PKD2; the disease is hepatocellular carcinoma.