The observation that SDC3 overexpression, regardless of cell type, can contribute to fundamental biological processes (i.e. uptake and fibrillation) related to Aβ1–42 pathology, highlights SDCs, especially SDC3, the neuron specific member of the SDC family with increased expression in AD brains as important players in the pathophysiologic events of neurodegeneration. This evidence concerns the gene SDC3 and Alzheimer disease.