Activation in the alerting network as elicited by the attention network task (ANT) — comprising the LC as well as right lateralized fronto-parietal regions particularly important for anxiety-related arousal regulation19,20 — was investigated dependent on HCRTR1 rs2271933 genotype and in correlation with dimensional measures of agoraphobic cognitions in an extended sample of healthy probands. This evidence concerns the gene HCRTR1 and Anxiety.