In this context, it is important to note that although the serum level of ALT is the most commonly used parameter for assessing hepatitis activity, it has been reported that 24.6% to 61.9% of chronic HBV infected patients with either normal or slightly raised ALT (<2 ULN) were diagnosed with moderate or severe hepatic inflammation and/or fibrosis5–7. The gene discussed is GPT; the disease is inflammation.