Demographic and biochemical parameters were compared between both groups (Table 2).While all variables, except age, sex, TBIL, ALP, HBV DNA, HBeAg and Anti-HBe, were significantly different between the two groups by univariate analysis, only GP73, ALB and AST were identified by multivariable analysis as independent factors significantly associated with the grade of liver inflammation (Table 2). This evidence concerns the gene HBE1 and Hepatitis.