To get further insight into the role of p62/SQSTM1 in TRAIL-R2/DR5 up-regulation and TRAIL DISC formation in PIM knockdown GBM cells, we first determined TRAIL-R2/DR5 levels in GBM cells depleted of p62/SQSTM1 by siRNA. Here, TNFRSF10B is linked to glioblastoma.