Intriguingly, under conditions of PIM knockdown-mediated sensitization to TRAIL, interaction between caspase-8 and p62/SQSTM1 was markedly reduced (Fig. 6B), suggesting that in GBM cells p62/SQSTM1 is playing a negative role in caspase-8 activation after TRAIL treatment. The gene discussed is TNFSF10; the disease is glioblastoma.