Importantly, overexpression of the p62/SQSTM1S332E mutant significantly attenuated apoptosis induced by the combination of PIM kinase inhibitor and TRAIL, confirming that the reduction of phosphorylation in p62/SQSTM1-Ser332 after PIM inhibition detected by MS-MS is implicated in TRAIL-R2/DR5 stabilization and mediates sensitization to TRAIL in GBM cells (Fig. 7E). The gene discussed is PIM1; the disease is glioblastoma.