Despite other data indicating a pro-apoptotic role of p62/SQSTM1 in some tumor cells facilitating full activation of ubiquitinated caspase-8 upon TRAIL receptor engagement by TRAIL36, our results demonstrate that in GBM cells p62/SQSTM1 interacts with the TRAIL DISC and plays a negative role in the activation of apoptosis by TRAIL. The gene discussed is TNFSF10; the disease is glioblastoma.