A recent in vitro study across >500 cell lines suggests that cancer cells with activating CCND1 genetic alternations (e.g., amplification, translocation) are sensitive to abemaciclib; paradoxically, CCND1 mRNA is positively correlated with IC50 of abemaciclib and high cyclin D1 protein expression is also weakly associated with abemaciclib resistance53. This evidence concerns the gene CCND1 and cancer.