To address this question, five anti-DR4 (clones C#1, C#2, C#5, C#11, C#16) and four anti-DR5 antibodies (clones C#21, C#22, C#23, C#24), were produced in larger quantities and evaluated, by methylene blue or Annexin V staining, for their ability to induce the loss of cell viability or apoptosis in a panel of human tumour cell lines sensitive or resistant to TRAIL-induced cell death12,33–35. The gene discussed is TNFSF10; the disease is neoplasm.