Despite the differences in tissue origins and mutation burdens between these two cancer types, SMARCA4-deficient NSCLC cell lines (n = 11) also express lower levels of cyclin D1 protein (Fig. 1a) and messenger RNA (mRNA; Fig. 1b) compared to SMARCA4-proficient NSCLC cell lines (n = 9), which consist of the major NSCLC subtypes with KRAS (n = 4) or EGFR (n = 3) mutations as well as those without these driver mutations (n = 2; Supplementary Data 1). Here, EGFR is linked to cancer.