SMARCA4 and non-small cell lung carcinoma: In addition to NSCLC, inactivating SMARCA4 mutations are known to be the sole genetic driver event in ~100% of small cell carcinoma of the ovary, hypercalcemic type (SCCOHT)12–14, which, unlike NSCLC, has a remarkably simple genome that harbors few mutations or chromosomal alterations15,16.