CBX8 and hepatocellular carcinoma: As shown in Figure S1E, shCBX8#2 was the most effective silencing oligo, and was selected for silencing CBX8 in SMMC-7721 and Sk-Hep-1 cells (designated as SMMC-7721-shCBX8 and Sk-Hep-1-shCBX8) for testing the oncogenic activity of CBX8 in HCC.