Meanwhile, IHC staining of the TMA slide showed that Cul4A was expressed in both cytoplasm and nucleus, and that the positive expression rate of Cul4A in ovarian tumor tissues (67.6%, 48/71 cases) was higher than that in normal interstitial tissue (26.7%, 4/15 cases), indicating that Cul4A was overexpressed in ovarian tumor tissue (Fig. 1b). The gene discussed is CUL4A; the disease is ovarian neoplasm.