Significant gene-sets and GWAS catalogue hits from GWEIS are detailed in Supplementary Tables 11-14, including for UKB Biocarta: GPCR pathway; Reactome: opioid signalling, neurotransmitter receptor binding and downstream transmission in the postsynaptic cell, transmission across chemical synapses, gastrin CREB signalling pathway via PKC and MAPK; GWAS catalogue: post bronchodilator FEV1/FVC ratio, migraine and body mass index. The gene discussed is CREB1; the disease is migraine disorder.