Previous studies have implicated these genes in liability to depression (see Supplementary Table 17), and three of them are genome-wide significant in gene-based tests from the latest meta-analysis of major depression that includes UKB (DCC, p = 2.57 × 10−14; DRD2, p = 5.35 × 10−14; and KYNU, p = 2.38 × 10−6; N = 807,553)79. The gene discussed is KYNU; the disease is depressive symptom measurement.