Moreover, LATS1 activity is highly suppressed by CpG island methylation in renal cell carcinoma and causes low LATS1 expression in 46.7% (14/30) of renal carcinoma tissues, indicating that LATS1 hypermethylation plays an important role in the downregulation of LATS1 in renal carcinoma8. This evidence concerns the gene LATS1 and hereditary clear cell renal cell carcinoma.