Moreover, LATS1 activity is highly suppressed by CpG island methylation in renal cell carcinoma and causes low LATS1 expression in 46.7% (14/30) of renal carcinoma tissues, indicating that LATS1 hypermethylation plays an important role in the downregulation of LATS1 in renal carcinoma8. Here, LATS1 is linked to renal cell carcinoma.