For example, caspase-11–mediated endothelial pyroptosis is requisite for endotoxemia-induced lung injury (33), while endothelial cell pyroptosis via caspase-1–dependent inflammasome activation leads to endothelial dysfunction in hyperhomocysteinemia-related vascular inflammation and atherosclerosis (34). This evidence concerns the gene CASP1 and endothelial dysfunction.