DEFA3 and Sepsis: In both assays, compared with WT mice and the mice with LCN, those carrying HCN of DEFA1/DEFA3 had significantly increased extravasation of dyes in the vessel beds of lungs, kidneys, and mesentery at 72 h after the initiation of sepsis (Fig. 3 A and B and SI Appendix, Fig. S7 A and B).