To further examine whether such a mechanism contributes to the deleterious effect of increased dose of DEFA1/DEFA3 on sepsis, BM-chimeric mice were generated by reconstituting lethally irradiated P2X7-deficient mice with BM from HCN of DEFA1/DEFA3, LCN of DEFA1/DEFA3, or WT mice. This evidence concerns the gene DEFA3 and Sepsis.