We subjected mice carrying the HCN of DEFA1/DEFA3 genes to the CLP model and treated them three times with the blocking antibody (300 μg, by tail vein injection; immediately, 24 and 48 h after performance of sepsis), or administered an equal amount of mouse IgG or an equal volume of normal saline (Fig. 6A). Here, DEFA3 is linked to Sepsis.