Immunohistochemistry revealed a low degree of intercellular adhesion protein 1 (ICAM-1) and vascular cell adhesion protein 1 (VCAM-1) expression in lungs of WT mice and mice with LCN of DEFA1/DEFA3, but a significantly increased expression of ICAM-1 and VCAM-1 in lungs of mice carrying HCN of DEFA1/DEFA3, at 24 h after sepsis onset (SI Appendix, Fig. S5 A–D). The gene discussed is ICAM1; the disease is Sepsis.