Consistent with the requirement of a responsive Nlrp1b allele for efficient pyroptosis induction by DPP8/DPP9 inhibitors, 1G244 more potently induced cytotoxicity in the BALB/c-derived myeloid leukemia cell line J774.A1 than in the wild-type B6 primary macrophages (Waumans et al, 2016). The gene discussed is DPP8; the disease is myeloid leukemia.