PAK2 and alkaline phosphatase measurement: The role of Group-I-PAKs in AP is not well understood, the recent study showed that PAK2 is a mediator upon FAKs, MAPKs, and PI3K pathways, and PAK2 mediates trypsin activation and ROS production in pancreatic acini, and leads to pancreatic acini apoptosis and necrosis [40].