Each gene appears to underpin key biological functions; loss of PIP4K2A (also called PIP4Kα) and PIP4K2B (also called PIP4Kβ) is able to reduce the rate of tumour growth in p53−/− mice [5]; loss of PIP4K2C (also called PIP4Kγ) triggers an autoimmune response in mouse models [6] and recently PIP4K2C has been shown to control the clearance of protein aggregates in a cellular model of Huntington’s disease [7]. Here, PIP4K2C is linked to juvenile Huntington disease.